The idea that the immune system may play a role in protecting against malignant disease is not new. Since the earliest days of immunology research, scientists have sought to understand the mechanisms by which the host immune system might recognize cancer cells, and to manipulate these responses for therapeutic gain. It has become clear that the key to immune recognition of tumors lies in the relationship between cells in the microenvironment of the tumor itself. This volume provides a comprehensive collection of techniques for establishing tumor cell lines, testing their immunogenicity, and characterizing the major effector cells, leading to protocols for manipulating antibody and T-cell receptor structure, preparing cytokine-secreting tumor cells and testing the efficiency of these new agents in preventing tumor growth. Researchers in immunology as a whole in addition to those interested in cancer immunology will find this volume to be an invaluable practical resource.